Chronic hypertension increases susceptibility to acute IOP challenge in rats

Z He; AJ Vingrys; JA Armitage; CT Nguyen; BV Bui

Journal article

Chronic hypertension increases susceptibility to acute IOP challenge in rats

Z He, AJ Vingrys, JA Armitage, CT Nguyen, BV Bui

Investigative Ophthalmology Visual Science | ASSOC RESEARCH VISION OPHTHALMOLOGY INC | Published : 2014

DOI: 10.1167/iovs.14-15207

Abstract

PURPOSE: To consider the effect of chronic arterial hypertension on the susceptibility of the retina to acute IOP challenge.METHODS: Anesthetized adult Long-Evans rats with normal (n = 5, receiving saline subcutaneously), chronic high blood pressure (BP) for 4 weeks (n = 15, Angiotensin II subcutaneously), and acute high BP for 1 hour (n = 10, Angiotensin II intravenously) underwent IOP elevation (10-120 mm Hg, 5 mm Hg steps each 3 minutes). During IOP elevation, retinal function and ocular blood flow were monitored with electroretinogram (ERG) and laser-Doppler flowmetry (LDF), respectively. Blood pressure was monitored via a femoral artery cannula. Electroretinogram and LDF responses are e..

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University of Melbourne Researchers

Algis Vingrys Author

Christine Nguyen Author

Bang Bui Author

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Grants

Awarded by NHMRC Project (Melbourne, Victoria, Australia)

Funding Acknowledgements

The authors thank Jonathan Bensley and Debbie Arena from the Department of Anatomy and Developmental Biology, Monash University, who assisted in the histology assay and analysis. Supported by the NHMRC Project Grant (566570, 1046203; Melbourne, Victoria, Australia).